DeepMind's AlphaGenome Atlas scores all 9B human DNA variants

A free API and 1PB of predictions ship today; Grok 4.7 is days out, and Samsung's €3B keeps Europe's open-weight stack independent.

Nowline Sep 8 11:00 PM banner

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  • Every possible variant, pre-scored

    The Atlas is roughly 1 petabyte — about 30x the AlphaFold database — covering all 9 billion single-nucleotide variants plus 100M+ indels from gnomAD, UK Biobank and All of Us, each carrying ~27,000 cell-type-specific predictions. A new AVI score collapses splicing, expression and loss-of-function signals into one number per variant.

  • Query it this weekend, free

    Request an API key on the AlphaGenome page, pip install the client, and feed DNA up to 1M base pairs for single-base-resolution predictions — free for non-commercial use, with a skill already wired into Google's Antigravity agent platform. Enough to prototype a rare-disease variant triage tool or a non-coding annotation pipeline.

  • The commercial catch

    The free key is non-commercial and rate-limited to thousands of predictions, not millions — large runs wait for the paid tier coming to Google Cloud. Static AVI score downloads, though, ship under a permissive license you can use commercially today.

  • Report: Grok 4.7 lands mid-September

    Musk says a ~2.1T-parameter Grok 4.7 — 40% bigger than 4.6, with supplemental SpaceX-data training — is roughly a week out, but xAI's docs still stop at 4.6 with no model ID, price or benchmarks. If you build on the xAI API, expect a new model and pricing reshuffle imminently; treat every spec as reportedly until it hits the sheet.

  • Elsewhere: Samsung backs Europe's open weights

    Mistral closed a €3B Series D led by Samsung at a ~$24B valuation — Europe's largest tech round — earmarked for its sovereign, open-weight stack. For anyone self-hosting Mistral models, it signals the open lineup keeps shipping independent of the US labs.